Epithelial Cell Adhesion Molecule

Preferred Label : Epithelial Cell Adhesion Molecule;

NCIt synonyms : Gastrointestinal Tumor-Associated Antigen 2; Membrane Component, Chromosome 4, Surface Marker 1; KSA Glycoprotein; M4S1 Protein; TROP-1; Epithelial Cellular Adhesive Molecule; Epithelial Glycoprotein 40; EGP40; Ep-CAM; GA733-2 Antigen; TACSTD1; KSA; EPCAM; Epithelial Glycoprotein 314; Adenocarcinoma-Associated Antigen; Major Gastrointestinal Tumor-Associated Protein GA733-2; EGP314; KS 1/4 Antigen; CD326; CD326 Antigen; Epithelial Glycoprotein; EGP; Tumor-Associated Calcium Signal Transducer 1; hEGP314; Epithelial Cell Surface Antigen; MOC31; Antigen CD326; Cell Surface Glycoprotein Trop-1; Tumor-Associated Calcium Signal Transducer-1;

NCIt definition : Epithelial cell adhesion molecule (314 aa, 35 kDa) is encoded by the human EPCAM gene. This protein is involved in both cell adhesion and cellular proliferation.;

NCIt note : Ep-CAM is a cell adhesion molecule expressed in epithelial cells and a ligand for leukocyte-associated immunoglobulin-like receptor 1 (LAIR1). Ep-CAM also binds to LAIR2. Ep-CAM may act to prevent an excessive inflammatory response. Over expression of Ep-CAM in breast cancer may be correlated with the histologic grade of the disease and a predictor of poor prognosis. (from OMIM 600718);

Details

Origin ID

C20209;

UMLS CUI

C0903677;

Automatic exact mappings (from CISMeF team)
- Epithelial Cell Adhesion Molecule [MeSH concept]
- Epithelial Cell Adhesion Molecule [MeSH Descriptor]
- Epithelial cellular adhesion molecule [OMIM gene]
- epithelial cell adhesion molecule [HGNC gene]
- epithelial cell adhesion molecule [ORDO Gene]
OMIM relation
- Epithelial cellular adhesion molecule [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- EPCAM protein, human [MeSH concept]
- EPCAM protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Ep-CAM [NCIt concept]
- Recombinant KSA Glycoprotein CO17-1A [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- EPCAM Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_gene_product_variant
- EPCAM Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_malfunction_associated_with_disease
- Colorectal Carcinoma [NCIt concept]
- Lung Adenocarcinoma [NCIt concept]
- Pancreatic Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Induction [NCIt concept]
is_target
- Anti-EpCAM Monoclonal Antibody AM-928 [NCIt concept]
- Anti-EpCAM/Anti-4-1BB Bispecific Antibody BNT314 [NCIt concept]
- Anti-EpCAM/Anti-CD3 Bispecific Antibody A-337 [NCIt concept]
- Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182 [NCIt concept]
- Anti-EpCAM/Anti-CD3 Bispecific Antibody M701 [NCIt concept]
- Catumaxomab [NCIt concept]
- Edrecolomab [NCIt concept]
- Oportuzumab Monatox [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients