Oportuzumab Monatox

Preferred Label : Oportuzumab Monatox;

NCIt related terms : VB4-845; anti-EpCAM-Pseudomonas-exotoxin fusion protein; Proxinium;

NCIt definition : A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Oportuzumab monatox binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells).;

UNII : 945CY7ZMI2;

CAS number : 945228-48-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 945228-48-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Proxinium; Vicinium;

Molecule name : VB4-845; VB4 845;

Codes from synonyms : CDR0000536228; CDR0000536229; CDR0000514409;

Details

Origin ID

C61307;

UMLS CUI

C4305686;

Automatic exact mappings (from CISMeF team)
- oportuzumab monatox [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- oportuzumab monatox [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epithelial Cell Adhesion Molecule [NCIt concept]

Keyword's position in hierarchy(ies) :

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