NCIt related terms : VB4-845; anti-EpCAM-Pseudomonas-exotoxin fusion protein; Proxinium;
NCIt definition : A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody
fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with
a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity.
Oportuzumab monatox binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas
exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates
elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein
synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety
of tumor cells and is frequently found in head and neck cancers.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain types of head and
neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal
antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM
(a protein on the surface of epithelial cells and some types of cancer cells).;
UNII : 945CY7ZMI2;
CAS number : 945228-48-8;
Drug name : Proxinium; Vicinium;
Molecule name : VB4-845; VB4 845;
Codes from synonyms : CDR0000536228; CDR0000536229; CDR0000514409;