" /> Oportuzumab Monatox - CISMeF





Preferred Label : Oportuzumab Monatox;

NCIt related terms : VB4-845; anti-EpCAM-Pseudomonas-exotoxin fusion protein; Proxinium;

NCIt definition : A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Oportuzumab monatox binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells).;

UNII : 945CY7ZMI2;

CAS number : 945228-48-8;

Drug name : Proxinium; Vicinium;

Molecule name : VB4-845; VB4 845;

Codes from synonyms : CDR0000536228; CDR0000536229; CDR0000514409;

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31/05/2025


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