Anti-EpCAM/Anti-CD3 Bispecific Antibody M701

Preferred Label : Anti-EpCAM/Anti-CD3 Bispecific Antibody M701;

NCIt synonyms : EpCAM x CD3 Bispecific Antibody M701;

NCIt definition : A human-mouse chimeric bispecific antibody directed against both CD3 and epithelial cell adhesion molecule (EpCAM), with potential immunomodulating and antineoplastic activities. Upon administration, anti-EpCAM/anti-CD3 bispecific antibody M701 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and EpCAM on EpCAM-expressing tumor cells. This activates and redirects CTLs to EpCAM-expressing tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells.;

Molecule name : M 701; M-701;

NCI Metathesaurus CUI : CL1647809;

Details

Origin ID

C178327;

UMLS CUI

C5554952;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epithelial Cell Adhesion Molecule [NCIt concept]

Keyword's position in hierarchy(ies) :

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