Preferred Label : Anti-EpCAM/Anti-CD3 Bispecific Antibody A-337;
NCIt synonyms : Itab A-337; Anti-EpCAM/Anti-EpCAM/Anti-CD3 Bispecific Antibody A-337; EpCAM x CD3 Bispecific Antibody BA3182; Recombinant Anti-EpCAM-CD3 Antibody A-337; EpCAM x EpCAM x CD3 Bispecific Antibody A-337;
NCIt definition : A T-cell engager (TCE) and bispecific antibody composed of two fragments targeting
the tumor-associated antigen (TAA) human epithelial cell adhesion molecule (Ep-CAM;
EpCAM; CD326) and one targeting the T-cell surface glycoprotein CD3, with potential
immunomodulating and antineoplastic activities. Upon administration, anti-EpCAM/anti-CD3
bispecific antibody A-337 targets and binds to EpCAM on EpCAM-expressing tumor cells
and CD3 on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to EpCAM-expressing
tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor
cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes
the proliferation, migration and invasiveness of tumor cells.;
Molecule name : A 337; A-337;
Origin ID : C202933;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
