NCIt definition : A humanized monoclonal antibody directed against the tumor-associated antigen (TAA)
epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326), with potential antineoplastic
activity. Upon administration, anti-EpCAM monoclonal antibody AM-928 targets and binds
to EpCAM on EpCAM-expressing tumor cells. This inhibits EpCAM-mediated signaling and
the proliferation of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated
on many tumor cell types, promotes the proliferation, migration and invasiveness of
tumor cells.;
Semantic type(s)