Preferred Label : Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182;
NCIt synonyms : Anti-EpCAM/CD3 Bispecific Antibody BA3182; Anti-EpCAM/CD3 CAB-bispecific T-cell Engager Antibody BA3182; EpCAM x CD3 Bispecific Antibody BA3182;
NCIt definition : A conditionally active biologic (CAB) and bispecific antibody directed against both
the tumor-associated antigen (TAA) human epithelial cell adhesion molecule (Ep-CAM;
EpCAM; CD326) and T-cell surface glycoprotein CD3 epsilon chain (CD3E), with potential
immunomodulating and antineoplastic activities. Upon administration and specific activation
in the tumor microenvironment (TME), anti-EpCAM/anti-CD3 bispecific antibody BA3182
targets and binds to both EpCAM on EpCAM-expressing tumor cells and CD3E on cytotoxic
T-lymphocytes (CTLs) within the TME. This activates and redirects CTLs to EpCAM-expressing
tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor
cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes
the proliferation, migration and invasiveness of tumor cells. Negatively charged,
physiologically-occurring molecules interact with positively charged areas on the
protein surface to prevent the activation of BA3182 outside the TME. In the acidic
TME, the negatively charged molecules are neutralized and released, allowing the binding
to EpCAM and CD3E. This may reduce systemic toxicity.;
Molecule name : BA 3182; BA-3182;
NCI Metathesaurus CUI : CL1907357;
Origin ID : C200082;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
