NCIt definition : An Fc-inert bispecific antibody directed against the tumor-associated antigen (TAA)
human epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326) and the costimulatory
receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9),
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-EpCAM/anti-4-1BB bispecific antibody BNT314 simultaneously targets and binds
to both EpCAM expressed on tumor cells and 4-1BB expressed on a variety of leukocyte
subsets including activated T-lymphocytes. This crosslinks EpCAM-expressing tumor
cells and 4-1BB-expressing T-cells, and activates 4-1BB signaling locally in the tumor
microenvironment (TME). This results in cytotoxic T-cell co-stimulation and enhances
T-lymphocyte-mediated anti-tumor activity. EpCAM, a cell surface protein upregulated
on many tumor cell types, promotes the proliferation, migration and invasiveness of
tumor cells. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily
(TNFRSF), is an inducible costimulatory receptor that plays a key role in T-cell proliferation,
survival and cytolytic activity.;
Molecule name : GEN-1059; GEN 1059; BNT 314; BNT-314;
Semantic type(s)