NCIt definition : A Fc-engineered agonistic antibody targeting the human B-cell surface antigen CD40,
with potential immunostimulatory and antineoplastic activities. Upon intratumoral
administration, 2141-V11 targets and binds to CD40 on a variety of immune cell types.
This induces CD40-dependent signaling pathways, triggers the proliferation and activation
of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced
cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a
cell surface receptor and member of the tumor necrosis factor receptor superfamily
(TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages
and B-cells, and plays a key role in the activation of the immune system.;
Semantic type(s)