Preferred Label : Anti-CD40 Agonist Monoclonal Antibody MIL97;
NCIt synonyms : Anti-CD40 Agonist Antibody 2141-V11;
NCIt definition : A recombinant, humanized, agonistic monoclonal antibody targeting the B-cell surface
antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon
administration, anti-CD40 agonist monoclonal antibody MIL97 targets and binds to CD40
on a variety of immune cell types. This induces CD40-dependent signaling pathways,
triggers the proliferation and activation of antigen-presenting cells (APCs) and activates
T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune
response against tumor cells. CD40, a cell surface receptor and member of the tumor
necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells,
such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the
activation of the immune system.;
Molecule name : MIL-97; MIL 97;
NCI Metathesaurus CUI : CL1664646;
Origin ID : C181768;
UMLS CUI : C5557254;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
