NCIt definition : A humanized agonistic antibody targeting the immune checkpoint human B-cell surface
antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon
administration, anti-CD40 agonist antibody YH003 targets and binds to CD40 on a variety
of immune cell types. This induces CD40-dependent signaling pathways, triggers the
proliferation and activation of antigen-presenting cells (APCs) and activates T-cells.
This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response
against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis
factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as
dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation
of the immune system.;
Semantic type(s)