NCIt synonyms : MGC10442; B Lymphoid Tyrosine Kinase wt Allele;
NCIt definition : Human BLK wild-type allele is located within 8p23-p22 and is approximately 71 kb in
length. This allele, which encodes tyrosine-protein kinase BLK protein, plays a putative
role in B-cell-specific signal transduction.;
NCIt note : The BLK gene expresses two transcripts; however, these are produced by two distinct
promoter elements within this gene and may be regulated by different trans-activation
factors. NERF-2, an Ets transcription family member, is a trans-activator of BLK gene
expression.;