Darbepoetin Alfa

Preferred Label : Darbepoetin Alfa;

NCIt synonyms : Novel Erythropoiesis Stimulating Protein; NESP;

NCIt definition : A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. (NCI04);

Alternative definition : NCI-GLOSS: A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics.;

UNII : 15UQ94PT4P;

CAS number : 209810-58-2;

Drug name : Nespo; Aranesp;

NSC code : 729969;

Codes from synonyms : CDR0000256550; 140;

Details

Origin ID

C1878;

UMLS CUI

C0937950;

CISMeF manual mappings
- Darbepoetin alfa [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Darbepoetin alfa [MeSH Descriptor]
- Darbepoetin alfa (substance) [SNOMED CT concept]
- Product containing darbepoetin alfa (medicinal product) [SNOMED CT concept]
- darbepoetin alfa [ATC Code]
- darbepoetin alfa [MeSH concept]
Validated automatic mappings to BTNT
- darbepoetin alfa [ATC Code]
chemical_or_drug_affects_gene_product
- Erythropoietin Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Activation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- B-Cell Activation [NCIt concept]
- Hematopoiesis Induction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Erythropoietin Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Darbepoetin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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