Preferred Label : Adhesion Molecules on Lymphocyte Pathway;
NCIt related terms : Adhesion Molecules on Lymphocyte;
Alternative definition : BIOCARTA: B cell and T cell lymphocytes interact with a variety of cells as part of
their immune function, circulating and homing in on specific stimuli in tissues like
inflammatory signals. The interaction of lymphocytes with other cell types like vascular
endothelial cells requires transmembrane adhesion molecules like VLA-4, LFA-1, CD44,
CD31 and L-selectin. Each of these lymphocyte adhesion molecules interacts with specific
ligands expressed on cells like endothelial cells to moderate adhesion between cells.
CD44 is an adhesion molecule with many roles, including interaction of leukocytes
with endothelial cells in response to inflammation, with the most often studied ligand
being hyaluronan, a component of the extracellular matrix. LFA-1, Leukocyte function-associated
molecule 1, is an integrin composed of two subunits, CD11a and CD18. LFA-1 moderates
adhesion of lymphocytes with other cells and also transduces signals into cells through
interaction with ICAM-1 expressed on endothelial cells. Expression of ICAM-1 (CD54)
is increased by inflammatory signals, increasing adhesion and permeation of lymphocytes
into inflamed tissues. VLA-4 is another integrin expressed on lymphocytes that plays
a role in adhesion through interaction with its adhesion partner on endothelial cells,
VCAM-1. L-selectin appears to mediate adhesion through binding of a lectin-like domain
to carbohydrates. PECAM-1 (CD31) is expressed on endothelial cells and is involved
in angiogenesis as well as adhesion between cells. VAP-1 is an additional protein
expressed by lymphocytes and involved in adhesion to vascular endothelial cells. (This
definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_lymphocytePathway;
Origin ID : C91303;
UMLS CUI : C2984144;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
