Integrin Alpha4/Beta1

Preferred Label : Integrin Alpha4/Beta1;

NCIt synonyms : Very Late Antigen-4; Alpha4/Beta1; Very Late Activation Antigen-4; CD49d-CD29; VLA4; CD49d/CD29; Alpha-4/Beta-1; VLA-4; VLA-4 Receptor; Alpha4Beta1 Integrin; Integrin Alpha-4/Beta-1; Integrin alpha4beta1;

NCIt definition : Integrin alpha4/beta1 is a protein complex comprised of a heterodimer of integrin alpha4 and integrin beta1. This complex plays a role in cell-cell adhesion, cell-matrix adhesion, inflammation, hematopoietic cell homing and immune system function.;

NCIt note : Integrin alpha4/beta1 binds to VCAM-1 expressed on leukocyte plasma membranes.;

Details

Origin ID

C97745;

UMLS CUI

C0209606;

Currated CISMeF NLP mapping
- integrin alpha4beta1 [MeSH Descriptor]
- integrin alpha4beta1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- integrin alpha4beta1 [MeSH concept]
- integrin alpha4beta1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Adhesion Molecule [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Ligand Binding [NCIt concept]
has_gene_product_element
- Integrin Alpha-4 [NCIt concept]
- Integrin Beta-1 [NCIt concept]
is_target
- Alintegimod [NCIt concept]
- Copper Cu 64-CB-TE1A1P-PEG4-LLP2A [NCIt concept]
related_to_genetic_biomarker
- ITGA4 Gene [NCIt concept]
- ITGB1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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