ICOS wt Allele

Preferred Label : ICOS wt Allele;

NCIt synonyms : Activation-Inducible Lymphocyte Immunomediatory Molecule Gene; Inducible T-Cell Co-Stimulator wt Allele; MGC39850; Inducible Costimulatory Gene; CD278; AILIM;

NCIt definition : Human ICOS wild-type allele is located in the vicinity of 2q33 and is approximately 25 kb in length. This allele, which encodes inducible T-cell costimulator protein, plays a role in the modulation of T-cell mediated immunity. Mutation of the gene is associated with common variable immunodeficiency type 1.;

NCIt note : Expression of the ICOS gene may enhance Th17 cell anti-tumor activity. (Sci Transl Med 2010; 2: in press.);

GenBank Accession Number : AB023135;

Details

Origin ID

C94802;

UMLS CUI

C2986687;

OMIM relation
- Inducible t-cell costimulator [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Common Variable Immunodeficiency [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 2q33 [NCIt concept]
gene_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Primary Immunodeficiency Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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