IL2 wt Allele - CISMeF

Preferred Label : IL2 wt Allele;

NCIt synonyms : T Cell Growth Factor Gene; Interleukin 2 wt Allele; Aldesleukin Gene; IL-2 Gene; T-Cell Growth Factor Gene; TCGF Gene; Interleukin 2 Precursor Gene; Lymphokine Gene;

NCIt definition : Human IL2 wild-type allele is located within 4q26-q27 and is approximately 5 kb in length. This allele, which encodes interleukin-2 protein, plays a role in the proliferation of T and B lymphocytes. IL2 also has a putative role in immune responses to antigenic stimuli. Further, the expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene.;

GenBank Accession Number : NM_000586;

Details

Origin ID

C50934;

UMLS CUI

C1705753;

OMIM relation
- Interleukin 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 4: 123735485-123730230 [NCIt concept]
gene_in_chromosomal_location
- 4q26-q27 [NCIt concept]
gene_is_element_in_pathway
- 4-1BB-Dependent Immune Response Pathway [NCIt concept]
- Allograft Rejection Pathway [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Hematopoiesis Pathway [NCIt concept]
- IL12/STAT4 Signaling Pathway [NCIt concept]
- IL18 Signaling Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- OX40 Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Activation Co-Stimulatory Signaling Pathway [NCIt concept]
- T-Cell Activation Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
gene_plays_role_in_process
- B Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- T-Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

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