Preferred Label : OX40 Signaling Pathway;
Alternative definition : BIOCARTA: Two key features of the immune system are the clonal expansion of B cells
and T cells in response to antigens, and the potentiation of future immune responses
by long-lived memory cells. CD4-expressing T cells require costimulatory signals along
with antigen stimulation to mount an effective immune response. CD28 has been widely
characterized as a costimulatory receptor for CD4 T cells. OX40, also called CD134,
is another transmembrane receptor protein expressed by CD4 T cells that provides a
costimulatory signal for T cell activation by antigen. The OX40L ligand for OX40 is
expressed as a transmembrane protein by antigen-presenting cells, and is required
for function of antigen-presenting cells. The T cell costimulatory signal provided
by the OX40/OX40L interaction increases the clonal amplification of antigen-specific
T cells and the survival of memory T cells that respond to this antigen. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_ox40Pathway;
Origin ID : C39175;
UMLS CUI : C1518522;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
