Interleukin-15

Preferred Label : Interleukin-15;

NCIt synonyms : Interleukin 15; IL15; IL-15; MGC9721; Interleukin-15 Precursor; IL15 Protein;

NCIt definition : Interleukin-15 (162 aa, 18 kDa) is encoded by the human IL15 gene. This protein plays a role in the regulation of both proliferation and activation of both T-cells and natural killer cells.;

NCIt note : Interleukin-15 and interleukin-2 bind common hematopoietin receptor subunits; therefore, they may compete for the same receptor, and negatively regulate each other's activity. The number of CD8 memory cells is controlled by a balance between this cytokine and IL2.;

Details

Origin ID

C20517;

UMLS CUI

C3252356;

Currated CISMeF NLP mapping
- Interleukin-15 [FMA entity]
- Interleukin-15 [MeSH Descriptor]
- Interleukin-15 [MeSH concept]
OMIM relation
- Interleukin 15 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IL15 protein, human [MeSH concept]
- IL15 protein, human [MeSH Supplementary Concept]
- Interleukin-15 [FMA entity]
- Interleukin-15 [MeSH concept]
- Interleukin-15 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- IL15 Gene [NCIt concept]
- Interleukin Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- T-Cell Activation [NCIt concept]
- T-Cell Proliferation [NCIt concept]
is_target
- Ordesekimab [NCIt concept]

Keyword's position in hierarchy(ies) :

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