" /> Ordesekimab - CISMeF





Preferred Label : Ordesekimab;

NCIt synonyms : HuMab-IL15 AMG 714; HUMAX-IL 15; Anti-IL-15 Monoclonal Antibody AMG 714;

NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human pro-inflammatory cytokine interleukin-15 (IL-15), with potential anti-inflammatory, immunomodulating and antineoplastic activities. Upon administration, ordesekimab binds to and neutralizes IL-15, thereby preventing IL-15-mediated pro-inflammatory signaling. By inhibiting IL-15-mediated immune responses, ordesekimab decreases natural killer (NK) cell activation and proliferation, reduces T-cell infiltration, increases T-cell apoptosis, and may prevent the growth of IL-15-driven cancer cells. IL-15 plays a key role in inflammation and is associated with a variety of autoimmune and inflammatory disorders as well as with cell proliferation in certain cancer types, such as T-cell lymphomas. IL-15 is required for the proliferation of certain T-cells and NK cells.;

UNII : EJ48MR05C3;

CAS number : 2394931-19-0;

Molecule name : AMG 714; AMG714;

NCI Metathesaurus CUI : CL507916;

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24/05/2025


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