NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human pro-inflammatory
cytokine interleukin-15 (IL-15), with potential anti-inflammatory, immunomodulating
and antineoplastic activities. Upon administration, ordesekimab binds to and neutralizes
IL-15, thereby preventing IL-15-mediated pro-inflammatory signaling. By inhibiting
IL-15-mediated immune responses, ordesekimab decreases natural killer (NK) cell activation
and proliferation, reduces T-cell infiltration, increases T-cell apoptosis, and may
prevent the growth of IL-15-driven cancer cells. IL-15 plays a key role in inflammation
and is associated with a variety of autoimmune and inflammatory disorders as well
as with cell proliferation in certain cancer types, such as T-cell lymphomas. IL-15
is required for the proliferation of certain T-cells and NK cells.;