Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1;

NCIt synonyms : MAPK/ERK Kinase Kinase Kinase 1; EC 2.7.11.1; Hematopoietic Progenitor Kinase; MAP4K1; MEK Kinase Kinase 1; MEKKK 1; Hematopoietic Progenitor Kinase 1;

NCIt definition : Mitogen-activated protein kinase kinase kinase kinase 1 (833 aa, 91 kDa) is encoded by the human MAP4K1 gene. This protein plays a role in the modulation of serine/threonine kinase-dependent signaling pathways.;

Details

Origin ID

C150080;

UMLS CUI

C0531165;

Automatic exact mappings (from CISMeF team)
- Mitogen-activated protein kinase kinase kinase kinase 1 [OMIM gene]
- hematopoietic progenitor kinase 1 [MeSH concept]
- hematopoietic progenitor kinase 1 [MeSH Supplementary Concept]
- mitogen-activated protein kinase kinase kinase kinase 1 [HGNC gene]
OMIM relation
- Mitogen-activated protein kinase kinase kinase kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MAP4K1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP4K1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- B-Cell Immune Response Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- JNK Signaling in the CD4+ TCR Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
gene_product_plays_role_in_biological_process
- Hematopoietic Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
is_target
- Hpk1 Inhibitor BGB-15025 [NCIt concept]
- Hpk1 Inhibitor BGB-26808 [NCIt concept]
- Hpk1 Inhibitor CFI-402411 [NCIt concept]
- Hpk1 Inhibitor FB849 [NCIt concept]
- Hpk1 Inhibitor GRC 54276 [NCIt concept]
- Hpk1 Inhibitor NDI-101150 [NCIt concept]
- Hpk1 Inhibitor PF-07265028 [NCIt concept]
- Hpk1 Inhibitor PRJ1-3024 [NCIt concept]

Keyword's position in hierarchy(ies) :

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