Preferred Label : Hpk1 Inhibitor FB849;
NCIt synonyms : Hematopoietic Progenitor Kinase 1 Inhibitor FB849;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine enzyme hematopoietic progenitor
kinase 1 (Hpk1; Hpk-1; mitogen-activated protein kinase kinase kinase kinase 1; MAP4K1;
MEKKK1), with potential immunostimulating and antineoplastic activities. Upon oral
administration, Hpk1 inhibitor FB849 targets, binds to and inhibits the activity of
Hpk1. This inhibits Hpk1-mediated signaling pathways and prevents Hpk1-mediated immunosuppression
by preventing the inhibition of T cell receptors (TCR) signaling and effector T-cells,
disrupting abnormal cytokine expression, and abrogating the immunosuppressive tumor
microenvironment (TME). This may activate a cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. Hpk1, expressed in hematopoietic cells, is a
negative regulator of TCR signaling and T- and B-cell activation.;
Molecule name : FB-849; FB 849;
NCI Metathesaurus CUI : CL1907105;
Origin ID : C200282;
UMLS CUI : C5854508;
Semantic type(s)
- concept_is_in_subset
- has_target
