Preferred Label : Hpk1 Inhibitor BGB-15025;
NCIt synonyms : Hpk-1 Inhibitor BGB-15025; Hematopoietic Progenitor Kinase 1 Inhibitor BGB-15025;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine enzyme hematopoietic progenitor
kinase-1 (Hpk1; Hpk-1; mitogen-activated protein kinase kinase kinase kinase 1; MAP4K1;
MEKKK1), with potential immunostimulating and antineoplastic activities. Upon oral
administration, Hpk1 inhibitor BGB-15025 targets, binds to and inhibits the activity
of Hpk1. This inhibits Hpk1-mediated signaling pathways and prevents Hpk1-mediated
immunosuppression by preventing the inhibition of T cell receptors (TCR) signaling
and effector T-cells, disrupting abnormal cytokine expression, and abrogating the
immunosuppressive tumor microenvironment (TME). This may activate a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells. Hpk1, expressed in hematopoietic
cells, is a negative regulator of TCR signaling and T- and B-cell activation.;
Molecule name : BGB-15025; BGB 15025;
NCI Metathesaurus CUI : CL1648209;
Origin ID : C178833;
UMLS CUI : C5555232;
Semantic type(s)
- concept_is_in_subset
- has_target
