Preferred Label : Hpk1 Inhibitor CFI-402411;
NCIt synonyms : Hematopoietic Progenitor Kinase 1 Inhibitor CFI-402411; Hpk-1 Inhibitor CFI-402411;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine enzyme hematopoietic progenitor
kinase-1 (Hpk1; Hpk-1; mitogen-activated protein kinase kinase kinase kinase 1; MAP4K1),
with potential immunostimulating and antineoplastic activities. Upon oral administration,
Hpk1 inhibitor CFI-402411 targets, binds to and inhibits the activity of Hpk1. This
inhibits Hpk1-mediated signaling pathways and inhibits the proliferation of Hpk1-expressing
tumor cells. In addition, CFI-402411 prevents Hpk1-mediated immunosuppression by preventing
the inhibition of T cell receptors (TCR) signaling and effector T-cells, disrupting
abnormal cytokine expression, and abrogating the immunosuppressive tumor microenvironment
(TME). This may activate a cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells. Hpk1 is expressed in hematopoietic cells and a negative regulator of
TCR and T- and B-cell activation.;
Molecule name : CFI 402411; CFI-402411;
NCI Metathesaurus CUI : CL1642797;
Origin ID : C176963;
UMLS CUI : C5447521;
Semantic type(s)
- concept_is_in_subset
- has_target
