" /> TNFRSF1B wt Allele - CISMeF





Preferred Label : TNFRSF1B wt Allele;

NCIt synonyms : Tumor Necrosis Factor Receptor Superfamily, Member 1B wt Allele; CD120b; TNFR80; TNFBR; TBPII; TNFR2; p75; p75TNFR; TNFR1B; TNF-R-II; TNF-R75;

NCIt definition : Human TNFRSF1B wild-type allele is located within 1p36.3-p36.2 and is approximately 42 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 1B protein, plays a role in the mediation of tumor necrosis factor-alpha signaling.;

NCIt note : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for CD40 and TNF-mediated activation of NF-kappa B and programmed cell death. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, baculoviral IAP repeat-containing protein 1 (BIRC1/c-IAP1) and 2 (BIRC2/c-IAP2). BIRC1 has been shown to act as a ubiquitin ligase that induces the ubiquitination and degradation of this receptor, which may potentiate TNF-induced apoptosis. Knockout studies in mice suggested a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. (Entrez Gene); The TNFRSF1B gene is expressed as two isoforms that are produced by alternative splicing. One isoform has a transmembrane domain and the other is a secreted protein. (SwissProt);

GenBank Accession Number : NM_001066;

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12/05/2024


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