Cytosolic DNA-Sensing Pathway

Preferred Label : Cytosolic DNA-Sensing Pathway;

Alternative definition : KEGG: Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-kappa B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.;

KEGG ID : hsa04623;

Details

Origin ID

C91504;

UMLS CUI

C2984314;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Antiviral Innate Immune Response Receptor RIG-I [NCIt concept]
- Apoptosis-Associated Speck-Like Protein Containing A CARD [NCIt concept]
- C-C Motif Chemokine 4 [NCIt concept]
- C-C Motif Chemokine 5 [NCIt concept]
- C-X-C Motif Chemokine 10 [NCIt concept]
- Caspase-1 [NCIt concept]
- Cyclic GMP-AMP Synthase [NCIt concept]
- DNA-Directed RNA Polymerase III Subunit RPC10 [NCIt concept]
- DNA-Directed RNA Polymerase III Subunit RPC2 [NCIt concept]
- DNA-Directed RNA Polymerases I and III Subunit RPAC2 [NCIt concept]
- DNA-Directed RNA Polymerases I, II, and III Subunit RPABC5 [NCIt concept]
- Double-Stranded RNA-Specific Adenosine Deaminase [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon [NCIt concept]
- Interferon Alpha-1/13 [NCIt concept]
- Interferon Alpha-2 [NCIt concept]
- Interferon Beta [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-18 [NCIt concept]
- Interleukin-33 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Mitochondrial Antiviral-Signaling Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- Pyrin [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 3 [NCIt concept]
- Serine/Threonine-Protein Kinase TBK1 [NCIt concept]
- Stimulator of Interferon Genes Protein [NCIt concept]
- Three Prime Repair Exonuclease 1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
pathway_has_gene_element
- ADAR wt Allele [NCIt concept]
- CASP1 wt Allele [NCIt concept]
- CCL4 wt Allele [NCIt concept]
- CCL5 wt Allele [NCIt concept]
- CGAS wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CXCL10 wt Allele [NCIt concept]
- IFNA1 wt Allele [NCIt concept]
- IFNA13 wt Allele [NCIt concept]
- IFNA2 wt Allele [NCIt concept]
- IFNB1 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IKBKE wt Allele [NCIt concept]
- IL18 wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL33 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IRF7 wt Allele [NCIt concept]
- MAVS wt Allele [NCIt concept]
- MEFV wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- POLR1D wt Allele [NCIt concept]
- POLR2L wt Allele [NCIt concept]
- POLR3B wt Allele [NCIt concept]
- POLR3K wt Allele [NCIt concept]
- PYCARD wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIGI wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- RIPK3 wt Allele [NCIt concept]
- STING1 wt Allele [NCIt concept]
- TBK1 wt Allele [NCIt concept]
- TREX1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients