Preferred Label : RIPK1 Inhibitor GSK3145095;
NCIt synonyms : Receptor-interacting Serine/Threonine-protein Kinase 1 Inhibitor GSK3145095;
NCIt related terms : GSK-3145095;
NCIt definition : An orally available, small-molecule inhibitor of receptor-interacting serine/threonine-protein
kinase 1 (RIPK1; receptor-interacting protein 1; RIP1) with potential antineoplastic
and immunomodulatory activities. Upon administration, GSK3145095 disrupts RIPK1-mediated
signaling, which may reduce C-X-C motif chemokine ligand 1 (CXCL1)-driven recruitment
and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) in the
tumor microenvironment (TME). This allows effector cells, such as natural killer (NK)
cells and cytotoxic T-lymphocytes (CTLs), to kill and eliminate cancer cells. RIPK1,
a serine-threonine kinase that normally plays a key role in inflammation and cell
death in response to tissue damage and pathogen recognition, is overexpressed in certain
cancer types and may be associated with oncogenesis and promotion of the immunosuppressive
nature of the TME.;
UNII : B4D3WPS7JY;
CAS number : 1622849-43-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1622849-43-7
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G-SRS /a ;
Molecule name : GSK 3145095; GSK-3145095;
NCI Metathesaurus CUI : CL935900;
Origin ID : C156737;
UMLS CUI : C4745028;
Semantic type(s)
- concept_is_in_subset
- has_target
