Nuclear Receptor Corepressor 2

Preferred Label : Nuclear Receptor Corepressor 2;

NCIt synonyms : NCOR2; T3 Receptor-associating Factor; Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors; SMRT; CTG Repeat Protein 26; SMAP270; Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor; N-CoR2; TRAC; Nuclear Receptor Co-Repressor 2; Nuclear Receptor Co-Repressor-2;

NCIt definition : Nuclear receptor corepressor 2 (2525 aa, 275 kDa) is encoded by the human NCOR2 gene. This protein plays a role in both chromatin remodeling and the repression of hormone receptor-mediated transcription.;

NCIt note : SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (OMIM);

Details

Origin ID

C19891;

UMLS CUI

C1307876;

Automatic exact mappings (from CISMeF team)
- Nuclear receptor corepressor 2 [OMIM gene]
- T-cell receptor alpha chain constant region [OMIM gene]
- T-cell receptor alpha constant [ORDO Gene]
- Trachea [LOINC System]
- Trachea [LOINC System]
- nuclear receptor corepressor 2 [HGNC gene]
Currated CISMeF NLP mapping
- nuclear receptor Co-Repressor 2 [MeSH Descriptor]
- nuclear receptor Co-Repressor 2 [MeSH concept]
OMIM relation
- Nuclear receptor corepressor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NCOR2 protein, human [MeSH Supplementary Concept]
- NCOR2 protein, human [MeSH concept]
- nuclear receptor Co-Repressor 2 [MeSH concept]
- nuclear receptor Co-Repressor 2 [MeSH Descriptor]
gene_encodes_gene_product
- NCOR2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- SANT Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chromatin Remodeling Complex and Coactivator Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- HDAC Class I Signaling Pathway [NCIt concept]
- HDAC Class II Signaling Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- Retinoic Acid Receptor Family-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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