SANT Domain - CISMeF

Preferred Label : SANT Domain;

NCIt synonyms : SWI3/ADA2/N-CoR/TFIIIB Domain; MYB-Like DNA-Binding Domain;

NCIt definition : The SANT domain is found in several transcriptional regulatory proteins identified through consistent homology to the c-MYB repeat DNA binding domain, suggesting that SANT domains also bind DNA. Folded into three alpha helices as doublets or singlets in many proteins, the SANT domain family specifically recognizes the sequence YAAC(G/T)G. The SANT domain is a repeated motif in N-CoR, the nuclear receptor co-repressor. Single copies of SANT occur in yeast nuclear chromatin remodeling proteins SWI3 (SWI/SNF transcription subunit), ADA2 (ADA adaptor/HAT complex), and a TFIIIB transcription subunit. SANT domains may mediate functional interactions with histone N-terminal tails. (NCI);

Details

Origin ID

C13663;

UMLS CUI

C1519125;

Associated anatomy of gene products
- Myb Oncogene Protein [NCIt concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- Deubiquitinase MYSM1 [NCIt concept]
- Metastasis-Associated Protein MTA1 [NCIt concept]
- Metastasis-Associated Protein MTA2 [NCIt concept]
- Myb/SANT-Like DNA-Binding Domain-Containing Protein 1 [NCIt concept]
- Myb/SANT-Like DNA-Binding Domain-Containing Protein 3 [NCIt concept]
- Nuclear Receptor Corepressor 1 [NCIt concept]
- Nuclear Receptor Corepressor 2 [NCIt concept]
- Probable Global Transcription Activator SNF2L1 [NCIt concept]
- SWI/SNF Complex Subunit SMARCC1 [NCIt concept]
- SWI/SNF Complex Subunit SMARCC2 [NCIt concept]
- SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin Subfamily A Member 5 [NCIt concept]
- Transcription Factor TFIIIB Component B'' homolog [NCIt concept]
- Transcriptional Adapter 2-Alpha [NCIt concept]
- Transcriptional-Regulating Factor 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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