Nuclear Receptor Corepressor 1

Preferred Label : Nuclear Receptor Corepressor 1;

NCIt synonyms : hN-CoR; hCIT529I10; Nuclear Receptor Corepressor; TRAC1; N-CoR; Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1; N-CoR1; NCOR1; Nuclear Receptor Co-Repressor-1; Nuclear Receptor Co-Repressor 1;

NCIt definition : Nuclear receptor corepressor 1 (2440 aa, 270 kDa) is encoded by the human NCOR1 gene. This protein is involved in both transcriptional repression and chromatin remodeling.;

NCIt note : N-CoR mediates ligand-independent inhibition of gene transcription by THR1 and RARs. The amino terminus of NCOR1 has striking homology to SMRT. NCOR1 and SMRT contain sequences similar to the NR box in two nuclear hormone receptor interaction domains. This CoRNR box is required for nuclear hormone receptor interaction. Sequences flanking the CoRNR box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (OMIM);

Details

Origin ID

C18285;

UMLS CUI

C1739838;

Currated CISMeF NLP mapping
- nuclear receptor Co-Repressor 1 [MeSH Descriptor]
- nuclear receptor Co-Repressor 1 [MeSH concept]
OMIM relation
- Nuclear receptor corepressor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NCOR1 protein, human [MeSH concept]
- NCOR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- NCOR1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- SANT Domain [NCIt concept]
gene_product_is_element_in_pathway
- ERBB4 Signaling Pathway [NCIt concept]
- Gene Expression Regulation by Vitamin D Receptor Pathway [NCIt concept]
- HDAC Class I Signaling Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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