Myb Oncogene Protein

Preferred Label : Myb Oncogene Protein;

NCIt definition : Human MYB Oncogene Protein is a product of a mutated variant (Oncogene MYB) of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. MYB Oncogene Protein disrupts normal cell function.;

Details

Origin ID

C17320;

UMLS CUI

C5441838;

Automatic exact mappings (from CISMeF team)
- oncogene proteins v-myb [MeSH Descriptor]
- oncogene proteins v-myb [MeSH concept]
OMIM relation
- Myb protooncogene, transcription factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- oncogene proteins v-myb [MeSH concept]
- oncogene proteins v-myb [MeSH Descriptor]
gene_encodes_gene_product
- Oncogene [NCIt concept]
- Oncogene MYB [NCIt concept]
gene_product_has_associated_anatomy
- SANT Domain [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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