Oncogene MYB - CISMeF

Preferred Label : Oncogene MYB;

NCIt synonyms : Oncogene AMV; MYB; Avian Myeloblastosis Viral (v-MYB) Oncogene Homolog; v-MYB Avian Myeloblastosis Viral Oncogene Homolog;

NCIt definition : Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. Oncogene MYB disrupts normal cell function.;

GenBank Accession Number : M15024;

Details

Origin ID

C16886;

UMLS CUI

C5441837;

Automatic exact mappings (from CISMeF team)
- MYB proto-oncogene, transcription factor [ORDO Gene]
- Myb protooncogene, transcription factor [OMIM gene]
- genes, myb [MeSH Descriptor]
- genes, myb [MeSH concept]
Currated CISMeF NLP mapping
- v-myb genes [MeSH concept]
OMIM relation
- Myb protooncogene, transcription factor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- MYB gene [LOINC component]
- MYB proto-oncogene, transcription factor [HGNC gene]
- Myb protooncogene, transcription factor [OMIM gene]
- v-myb genes [MeSH concept]
allele_in_chromosomal_location
- 6q22-q23 [NCIt concept]
gene_encodes_gene_product
- Myb Oncogene Protein [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Transcription [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tumorigenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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