" /> Histone Deacetylase 5 - CISMeF





Preferred Label : Histone Deacetylase 5;

NCIt synonyms : HDAC5; Antigen NY-CO-9; EC 3.5.1.98; HD5; Histone Deacetylase-5;

NCIt definition : Histone deacetylase 5 (1122 aa, 122 kDa) is encoded by the human HDAC5 gene. This protein is involved in chromatin silencing, transcriptional regulation and histone deacetylation.;

NCIt note : Histone deacetylase 5 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase. It is expressed differentially, is found in complexes with HDAC4 and HDAC3, and possesses deacetylation activity with all four core histones. MEF2A transcription factors interact with HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes. Muscle differentiation requires release of MEF2 from repression by HDACs. HDAC5 shuttles from nucleus to cytoplasm when myoblasts are triggered to differentiate. CAMK1 signaling prevents formation of MEF2/HDAC complexes and induces nuclear export of HDAC4 and HDAC5 by phosphorylation.;

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29/04/2024


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