TATA-Box-Binding Protein

Preferred Label : TATA-Box-Binding Protein;

NCIt synonyms : GTF2D; TBP; SCA17; TATA-Box Factor; GTF2D1; TATA Sequence-Binding Protein; TATA Box-Binding Protein; Transcription Initiation Factor TFIID TBP Subunit; TATA Box Binding Protein; TATA-Binding Factor; TATA-Binding Protein;

NCIt definition : TATA-box-binding protein (339 aa, 38 kDa) is encoded by the human TBP gene. This protein is involved in both DNA binding and gene transcription initiation.;

NCIt note : The TATA Binding Protein (TBP) is a DNA-binding component of the TFIID basal transcription factor of the class II genes (transcribed by RNA polymerase II), the TFIIIB class III transcription factor, and the TIF-1B (SL1) class I factor. Its name is derived from the A-T rich DNA motif that it binds to in the class II genes, most commonly TATAAAA.; The poly-Gln region of TATA-box-binding protein (amino acids 55-95 in the cannonical protein sequence) is highly polymorphic. There are 25 to 42 repeats in normal individuals and 47-63 repeats in patients with spinocerebellar ataxia 17.;

Details

Origin ID

C17578;

UMLS CUI

C1698296;

Currated CISMeF NLP mapping
- TATA-Box binding protein [MeSH concept]
- tata-box binding protein [MeSH Descriptor]
OMIM relation
- Tata box-binding protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TATA-Box binding protein [MeSH concept]
- TBP protein, human [MeSH Supplementary Concept]
- TBP protein, human [MeSH concept]
- tata-box binding protein [MeSH Descriptor]
gene_encodes_gene_product
- Basal Transcription Factor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TBP Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chromatin Remodeling Complex and Coactivator Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- Hypoxia Pathway [NCIt concept]
- RNA Polymerase III Transcription Pathway [NCIt concept]
- hSWI-SNF Pathway [NCIt concept]
gene_product_is_physical_part_of
- TFIID [NCIt concept]
- TFIIIB [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcription Initiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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