Preferred Label : Carbon C 11 YJH08;
NCIt synonyms : [11C]-5-(4-fluorobenzyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f
]-quinoline; [11C] YJH08; 11C-YJH08; 11C YJH08;
NCIt definition : A radioconjugate composed of YJH08, a synthetic glucocorticoid receptor (GR) agonist,
labeled with the positron-emitting isotope carbon C 11, with potential use in imaging
via positron emission tomography (PET). Upon intravenous administration of carbon
C 11 YJH08, the YJH08 moiety targets and binds to GR on tumor cells. Upon PET imaging,
this radioligand may allow for the assessment of GR-expressing tumor cells. This also
allows assessment of YJH08's pharmacokinetic profile and affinity of GR-positive tumor
cells. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription
factors, is overexpressed in certain tumor types and may be associated with tumor
cell proliferation and treatment resistance.;
NCI Metathesaurus CUI : CL1662095;
Origin ID : C179549;
UMLS CUI : C5555761;
Semantic type(s)
- concept_is_in_subset
- has_target
