Preferred Label : Glucocorticoid Receptor Antagonist ORIC-101;
NCIt synonyms : GR Antagonist ORIC-101; 19,21-Dinorchol-4-en-20(22)-yn-3-one, 17-Hydroxy-23,23-dimethyl-11-(4-(methyl(1-methylethyl)amino)phenyl)-,
(11.Beta.,17.Alpha.)-;
NCIt related terms : ORIC-101;
NCIt definition : A mifepristone-based steroidal glucocorticoid receptor (GR) antagonist with potential
antineoplastic activity. Upon oral administration, ORIC-101 selectively binds to GRs,
thereby inhibiting the activation of GR-mediated proliferative and anti-apoptotic
gene expression pathways. The GR, a member of the nuclear receptor superfamily of
ligand-dependent transcription factors, is overexpressed in certain tumor types and
may be associated with tumor cell proliferation and treatment resistance. Inhibition
of GR activity may potentially slow tumor cell growth and disease progression in certain
cancers. Due to its reduced androgen receptor (AR) agonistic activity and improved
cytochrome P450 2C8 (CYP2C8) and 2C9 (CYP2C9) inhibition profile, ORIC-101 may be
useful in the treatment of AR-positive tumors with reduced potential for drug-drug
interactions.;
UNII : VI6E2D3CYP;
CAS number : 2222344-98-9;
Molecule name : ORIC 101; ORIC-101;
NCI Metathesaurus CUI : CL970945;
Origin ID : C162509;
UMLS CUI : C5206611;
Semantic type(s)
- concept_is_in_subset
- has_target
