Lupus La Protein

Preferred Label : Lupus La Protein;

NCIt synonyms : SS-B/La Protein; La Autoantigen; SS-B; Autoantigen La; Sjoegren Syndrome Type B Antigen; La Ribonucleoprotein; Lupus La Antigen; SSB;

NCIt definition : Lupus La protein (408 aa, 47 kDa) is encoded by the human SSB gene. This protein is involved in the modulation of tRNA and mRNA metabolism.;

NCIt note : Patients with Sjogren syndrome and systemic lupus erythematosus produce autoantibodies that react with Lupus La protein.;

NCI Metathesaurus CUI : CL540189;

Details

Origin ID

C142145;

UMLS CUI

C4553537;

Automatic exact mappings (from CISMeF team)
- SS-B antigen [MeSH Supplementary Concept]
- Small rna-binding exonuclease protection factor la [OMIM gene]
- autoantigens [MeSH Descriptor]
- ribonucleoproteins [MeSH Descriptor]
- small RNA binding exonuclease protection factor La [HGNC gene]
- ss-b [EMDN type]
- ss-b [medical devices type]
OMIM relation
- Small rna-binding exonuclease protection factor la [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- SSB Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- RNA Recognition Motif [NCIt concept]
gene_product_is_element_in_pathway
- RNA Polymerase III Transcription Pathway [NCIt concept]
- Systemic Lupus Erythematosus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- RNA Binding [NCIt concept]
- RNA Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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