" /> General Transcription Factor IIH Subunit 1 - CISMeF





Preferred Label : General Transcription Factor IIH Subunit 1;

NCIt synonyms : BTF2 p62; GTF2H1; TFIIH Basal Transcription Factor Complex p62 Subunit; BTF2-p62; Basic Transcription Factor 62kDa Subunit; General Transcription Factor IIH Polypeptide 1; General Transcription Factor IIH1 62kDa; General Transcription Factor IIH1; General Transcription Factor-IIH1-62kDa;

NCIt definition : General transcription factor IIH subunit 1 (548 aa, 62 kDa) is encoded by the human GTF2H1 gene. This protein is involved in the modulation of both RNA polymerase II-mediated transcription and nucleotide excision repair.;

NCIt note : Expressed in testis by human GTF2H1 Gene, General Transcription Factor IIH1 62kDa is a subunit of TFIIH, a multisubunit factor of at least 10 proteins involved in transcription, nucleotide excision repair, and cell cycle regulation. p62 is one of six subunits that constitutes the TFIIH core; the holoenzyme contains the ternary kinase CAK complex. Lacking any known motifs or enzymatic activity p62 may have only an architectural role.;

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14/05/2024


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