Preferred Label : Transcription Initiation Factor TFIID Subunit 1;
NCIt synonyms : TAF1; TBP-Associated Factor RNA Polymerase II 250-kD; TBP-Associated Factor, Class II, 250 kDa; TAF1 RNA Polymerase II TATA Box Binding Protein-Associated Factor 250-kD; P250; CCG1 Protein; CCGS; TBP-Associated Factor 1; EC 2.7.11.1; TBP-Associated Factor 250 kDa; Transcription Initiation Factor TFIID 250 kDa Subunit; TATA Box-Binding Protein-Associated Factor 2A; Transcription Factor TFIID p250 Polypeptide; TAF2A; TAF1 RNA Polymerase II TATA Box Binding Protein; Cell Cycle Gene 1 Protein; RNA Polymerase IIA 250kD; TAF(II)250; TAFII250; TAFII-250; TAF-II-250 Protein; TATA Box-Binding Protein-Associated Factor 1;
NCIt definition : Transcription initiation factor TFIID subunit 1 (1872 aa, 213 kDa) is encoded by
the human TAF1 gene. This protein plays a role in protein phosphorylation, cell cycle
progression and RNA polymerase II-mediated transcription.;
NCIt note : TAF(II)250, the largest subunit of TFIID, may be phosphorylated by casein kinase II
and contains an HMG box and two bromodomains with highly charged helical bundles that
bind to diacetylated histone H4 tails. Variant 2 lacks 21 internal amino acids. Similar
to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal
Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit.
TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme,
binds to core promoter transcription start sites, and interacts with TBP, other TAFs,
and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation.
Essential for G1 progression, TAF1 links control of transcription to the cell cycle.
(from LocusLink, Swiss-Prot, OMIM); Protein_Has_Biochemical_Function: Ubiquitin-Activating/Conjugating Enzyme; Protein_Has_Isoforms: Isoforms 1,2; Protein_Interacts_With: Transcription Start Site, Histone H4, TFIIF Large Subunit,
TBP, TAFs, Transcriptional Regulators; Protein_Has_Structural_Domain_Or_Motif: Serine/Threonine Kinase Domain; Protein_Plays_Role_In_Biological_Process: G1 Progression, TFIID Assembly;
Origin ID : C17677;
UMLS CUI : C1146629;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
