" /> GTF2B wt Allele - CISMeF





Preferred Label : GTF2B wt Allele;

NCIt synonyms : TF2B Gene; GTF2B; RNA Polymerase II Transcription Factor IIB Gene; TFIIB Gene; Transcription Factor IIB Gene; General Transcription Factor IIB wt Allele;

NCIt definition : Human GTF2B wild-type allele is located within 1p22-p21 and is approximately 39 kb in length. This allele, which encodes transcription initiation factor IIB protein, is involved in transcription through the modulation of the formation of the RNA polymerase II preinitiation complex.;

NCIt note : The GTF2B (TFIIB) gene encodes a protein that is a general transcription factor and plays a central role in preinitiation complex assembly. TFIIB is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. TFIIB provides a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. BRE suppresses the basal level of transcription elicited by a core promoter, which increases the amplitude of transcriptional stimulation in the presence of an activator where an activator can disrupt the TFIIB-BRE interaction within a promoter-bound complex. The TFIIB gene is located at chromosome 1p22-p21 on the short arm of chromosome 1. (from PMID 11711430, LocusLink 2959);

GenBank Accession Number : NM_001514;

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18/05/2024


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