Preferred Label : RXR-alpha Variant-targeting Agent NM6603;
NCIt synonyms : Retinoid X Receptor Alpha Variant-targeting Agent NM6603; RXRA Variant-targeting Agent NM6603;
NCIt definition : An orally bioavailable small molecule agent that targets retinoid X receptor alpha
(RXR-alpha; RXRA) variant, with potential antineoplastic activity. Upon oral administration,
RXR-alpha variant-targeting agent NM6603 selectively targets and binds to RXR-alpha
variants and inhibits transforming growth factor-beta (TGFb)-mediated signaling pathway.
This abrogates TGF-beta-mediated immunosuppression in the tumor microenvironment (TME),
increases cytotoxic T-lymphocyte (CTL) activities, and inhibits tumor cell proliferation
in susceptible tumor cells. RXR-alpha, a transcription factor that plays an important
role in the regulation of the expression of multiple genes, is often modified in various
types of tumor cells.;
Molecule name : NM-6603; NM 6603;
Origin ID : C201713;
concept_is_in_subset
- has_target
