CARM1 Transcription Regulation Pathway

Preferred Label : CARM1 Transcription Regulation Pathway;

NCIt related terms : Transcription Regulation by Methyltransferase of CARM1;

Alternative definition : BIOCARTA: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_carm1Pathway;

Details

Origin ID

C39012;

UMLS CUI

C1511399;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- CREB-Binding Protein [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone H3.2 [NCIt concept]
- Histone-Arginine Methyltransferase CARM1 [NCIt concept]
- Myocyte-Specific Enhancer Factor 2C [NCIt concept]
- Nuclear Receptor Coactivator 3 [NCIt concept]
- Retinoic Acid Receptor Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]
pathway_has_gene_element
- CARM1 wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- MEF2C wt Allele [NCIt concept]
- NCOA3 wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKAR1A wt Allele [NCIt concept]
- PRKAR2A wt Allele [NCIt concept]
- RARA wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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