NCIt synonyms : Translocated Promoter Region, Nuclear Basket Protein wt Allele; Tumor Potentiating Region Gene; Translocated Promoter Region (to Activated MET Oncogene) Gene;
NCIt definition : Human TPR wild-type allele is located in the vicinity of 1q25 and is approximately
64 kb in length. This allele, which encodes nucleoprotein TPR, is involved in the
regulation of both the mitotic spindle checkpoint and nuclear pore transport. Chromosomal
rearrangement of this gene and the MET gene is associated with gastric cancer and
rearrangement of this gene and the NTRK1 gene is associated with papillary thyroid
carcinoma.;