" /> RET wt Allele - CISMeF





Preferred Label : RET wt Allele;

NCIt synonyms : MTC1; MEN2B; PTC; RET51; RET Proto-Oncogene (Multiple Endocrine Neoplasia and Medullary Thyroid Carcinoma 1, Hirschsprung Disease) wt Allele; HSCR1; Gene Rearranged During Transfection; CDHF12; MEN2A; RET; Rearranged During Transfection Protooncogene Gene;

NCIt definition : Human RET wild-type allele is located in the vicinity of 10q11.2 and is approximately 53 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase receptor ret protein, plays a role in neural crest development. Mutations in the gene are associated with multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.;

NCIt note : RET can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Two transcript variants encoding different isoforms have been found for this gene.;

GenBank Accession Number : NM_000323;

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06/05/2024


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