Preferred Label : RET Inhibitor HS-10365;
NCIt definition : An orally bioavailable selective inhibitor of the proto-oncogene receptor tyrosine
kinase rearranged during transfection (RET), with potential antineoplastic activity.
Upon oral administration, RET inhibitor HS-10365 selectively binds to and inhibits
the activity of RET. This results in an inhibition of cell growth of tumors that exhibit
increased RET activity. RET overexpression, activating mutations, and fusions result
in the upregulation and/or overactivation of RET tyrosine kinase activity in various
cancer cell types; dysregulation of RET activity plays a key role in the development
and progression of these cancers.;
Molecule name : HS-10365; HS 10365;
NCI Metathesaurus CUI : CL1778791;
Origin ID : C186653;
UMLS CUI : C5667069;
Semantic type(s)
- concept_is_in_subset
- has_target
