Preferred Label : Vebreltinib;
NCIt synonyms : Bozitinib; 6-(1-Cyclopropyl-1h-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine;
NCIt definition : An orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor
receptor; HGFR) with potential antineoplastic activity. Upon administration, vebreltinib
selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting
c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing
or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase
overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation,
survival, invasion, metastasis, and tumor angiogenesis.;
UNII : 2WZP8A9VFN;
CAS number : 1440964-89-5;
Molecule name : PLB-1001; APL-101; CBI-3103; CBT-101;
NCI Metathesaurus CUI : CL512997;
Origin ID : C129717;
UMLS CUI : C5554536;
Semantic type(s)
- concept_is_in_subset
- has_target
