NCIt definition : An orally bioavailable inhibitor of MET tyrosine kinase with potential antineoplastic
activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal
transduction pathways, which may induce apoptosis in tumor cells overexpressing this
kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor
or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated
in many tumor cell types; this protein plays key roles in tumor cell proliferation,
survival, invasion, and metastasis, and tumor angiogenesis.;