" /> Tepotinib - CISMeF





Preferred Label : Tepotinib;

NCIt synonyms : Benzonitrile, 3-(1,6-Dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo-3-pyridazinyl)-; c-Met Inhibitor MSC2156119J;

NCIt definition : An orally bioavailable inhibitor of MET tyrosine kinase with potential antineoplastic activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.;

UNII : 1IJV77EI07;

InChIKey : AHYMHWXQRWRBKT-UHFFFAOYSA-N;

CAS number : 1100598-32-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1100598-32-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : EMD 1214063; EMD-1214063; MSC-2156119J; MSC-2156119;

Codes from synonyms : 19782;

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14/05/2024


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