Preferred Label : Davutamig;
NCIt synonyms : Anti-c-Met Bispecific Antibody REGN5093; METxMET Bispecific Antibody REGN5093; METxMET Antibody REGN5093; MET x MET Bispecific Antibody REGN5093;
NCIt definition : A bispecific monoclonal antibody that targets two different epitopes of the human
tumor-associated antigen (TAA) MET (c-MET; hepatocyte growth factor receptor; HGFR),
with potential antineoplastic activity. Upon administration, davutamig targets and
binds to two different, non-overlapping epitopes on MET expressed on thd tumor cell
surface, thereby forming unique davutamig-MET complexes. The binding of davutamig
to the MET epitopes and the unique complex formation causes MET internalization and
degradation. This prevents MET-mediated signaling and inhibits growth of MET-driven
tumor cells. MET, a receptor tyrosine kinase, is overexpressed on the cell surfaces
of various solid tumor cell types where it is involved in epithelial-mesenchymal transition;
it plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.;
UNII : N2H0RP6IHR;
CAS number : 2648058-48-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2648058-48-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : REGN-5093; REGN 5093;
NCI Metathesaurus CUI : CL972415;
Origin ID : C167188;
UMLS CUI : C5783384;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
