Preferred Label : Tivantinib;
NCIt synonyms : c-Met Inhibitor ARQ 197; (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; ARQ 197;
NCIt definition : An orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic
activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal
transduction pathways, which may induce cell death in tumor cells overexpressing c-Met
protein or expressing constitutively activated c-Met protein. c-Met protein, the product
of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte
growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor
cell types and plays key roles in tumor cell proliferation, survival, invasion, and
metastasis, and tumor angiogenesis.;
UNII : PJ4H73IL17;
InChIKey : UCEQXRCJXIVODC-PMACEKPBSA-N;
CAS number : 905854-02-6;
Molecule name : ARQ 197; ARQ-197;
Chemical formula : C23H19N3O2;
Codes from synonyms : 499;
Origin ID : C62437;
UMLS CUI : C2987651;
Automatic exact mappings (from CISMeF team)
- ARQ 197 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
concept_is_in_subset
has_target