" /> Tivantinib - CISMeF





Preferred Label : Tivantinib;

NCIt synonyms : c-Met Inhibitor ARQ 197; (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; ARQ 197;

NCIt definition : An orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.;

UNII : PJ4H73IL17;

InChIKey : UCEQXRCJXIVODC-PMACEKPBSA-N;

CAS number : 905854-02-6;

Molecule name : ARQ 197; ARQ-197;

Chemical formula : C23H19N3O2;

Codes from synonyms : 499;

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10/05/2025


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