Preferred Label : Anti-c-Met Antibody-drug Conjugate BYON3521;
NCIt synonyms : Anti-c-Met ADC BYON3521; ADC BYON3521; Anti-c-Met/Duocarmycin Antibody-drug Conjugate BYON3521;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody against the tumor-associated antigen (TAA) proto-oncogene c-Met
(hepatocyte growth factor receptor; HGFR) site-specifically conjugated to a linker-duocarmycin
payload, with potential antineoplastic activity. Upon intravenous administration of
anti-c-Met ADC BYON3521, the monoclonal antibody moiety targets and binds to c-Met
expressed on tumor cells. Upon binding, the linker is cleaved inside the tumor thereby
releasing the duocarmycin payload. Duocarmycin binds to the minor groove of DNA, alkylates
adenine at the N3 position, and induces cell death in c-Met-expressing cancer cells.
c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types,
plays key roles in tumor cell proliferation, survival, invasion, metastasis and tumor
angiogenesis.;
Molecule name : BYON-3521; BYON 3521;
NCI Metathesaurus CUI : CL1792182;
Origin ID : C187340;
UMLS CUI : C5706408;
Semantic type(s)
- concept_is_in_subset
- has_target
