NCIt definition : A human, Fabs-in-tandem immunoglobulin (FIT-Ig)-based, tetravalent, bispecific antibody
targeting both the epidermal growth factor receptor EGFR and the hepatocyte growth
factor receptor (HGFR;; cMet; c-Met), with potential antineoplastic activity. Upon
administration, bafisontamab simultaneously targets and binds to wild-type or certain
mutant forms of both EGFR and c-Met expressed on cancer cells, thereby preventing
receptor phosphorylation. This prevents the activation of both EGFR- and c-Met-mediated
signaling pathways and results in the inhibition of tumor cell proliferation. EGFR
and c-Met, both upregulated or mutated in a variety of tumor cell types, play key
roles in tumor cell proliferation. In bafisontamab, the two antigen-binding fragments
(Fabs) are fused directly in a crisscross orientation resulting in four active and
independent antigen binding sites.;
Semantic type(s)