" /> Bafisontamab - CISMeF





Preferred Label : Bafisontamab;

NCIt synonyms : Anti-EGFR/Anti-c-Met Bispecific Antibody EMB-01; Anti-cMET/EGFR Bispecific Antibody EMB-01; Bispecific Antibody EMB-01; Anti-EGFR/c-Met Bispecific Antibody EMB-01;

NCIt definition : A human, Fabs-in-tandem immunoglobulin (FIT-Ig)-based, tetravalent, bispecific antibody targeting both the epidermal growth factor receptor EGFR and the hepatocyte growth factor receptor (HGFR;; cMet; c-Met), with potential antineoplastic activity. Upon administration, bafisontamab simultaneously targets and binds to wild-type or certain mutant forms of both EGFR and c-Met expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and c-Met-mediated signaling pathways and results in the inhibition of tumor cell proliferation. EGFR and c-Met, both upregulated or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation. In bafisontamab, the two antigen-binding fragments (Fabs) are fused directly in a crisscross orientation resulting in four active and independent antigen binding sites.;

UNII : G86X5QQ7M5;

CAS number : 2437210-79-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2437210-79-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : EMB-01; FIT-013a; EMB 01;

NCI Metathesaurus CUI : CL937694;

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10/05/2024


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